Serotonin syndrome is diagnosed based on clinical findings.

Older adults are at increased risk from polypharmacy.

It’s something to consider if a patient is on an increased dose of serotonergic medications (such as tramadol or antidepressants) or with a recent addition, resulting in clonus, agitation, sweating, hypertonia, and fever (temperature > 38°F).

Treatment is based on severity.